Influence of copper nanoparticles on the growth characteristics of tumors in white outbreed rats

Purpose of the study . To effect copper nanoparticles on characteristics transplanted tumors rats, as well to assess dependence method administration nanoparticles. Materials and methods In experiments 163 white outbred male 160–200 g, size growth rate sarcoma 45 Pliss' lymphosarcoma were determined in dynamics when a suspension physiological saline was injected intratumorally or intraperitoneally total dose 10 mg/kg. Nanoparticles had "core-shell" structure with variable diameter range 30–75 nm. Contrary other researches, we started exposure metal only become visible grown up sizes at which their spontaneous regression unlikely. Results most animals (up 89 %), significant antitumor effects obtained complete large volumes. The nanodispersed differed different histological structures patterns. Experiments transplantable, slowly growing showed decrease specific tumor after single injection (1.25 mg/kg), could be observed 4 injections (a 5 mg/kg). case rapidly model (Pliss' lymphosarcoma), rates caused by occurred later stages exposure, received 5–10 efficiency depended approach injection. Conclusion 45, intraperitoneal more effective than intratumoral one, while rats some advantages. results indicate that is promising factor. mechanisms under influence are discussed.